Canadian Headache Society guideline for migraine prophylaxis. Pringshelm, T., Davenport, W., Mackie, G., et al. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a doubleblind, placebo controlled, randomized study. Safarinejad, M.R., Safarinejad, S., Shafiei, N., et al. Curr Opin Clin Nutr Metab Care, 8(6), 641-6.ġ4. Clinical aspects of coenzyme Q10: an update. Efficacy of coenzyme Q10 in patients with cardiac failure: a metaanalysis of clinical trials. Coenzyme Q10: an independent predictor of mortality in chronic heart failure. Molyneux, S.L., Florkowski, C.M., George, P.M., et al. Randomized, double-blind, placebocontrolled pilot trial of reduced coenzyme Q10 for Parkinson’s disease. Yoritaka, A., Kawajiri, S., Yamamoto, Y., et al. Coenzyme Q (10), endothelial function and cardiovascular disease. Littarru, G.P., Tiano, L., Belardinelli, R., et al. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson’s disease. Shults, C.W., Flint Beal, M., Song, D., et al. Mitochondria targeted therapeutic approaches in Parkinson’s and Huntington’s diseases. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. Rosenfeldt, F.L., Haas, S.J., Krum, H., et al. Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q10 in elderly men and women. Yubero-Serrano, E.M., Delgado-Casado, N., Delgado-Lista, J., et al. Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation. Potgieter, M., Pretorius, E., Pepper, M.S., et al. 11-12 It also had clinical benefits for a number of other conditions, including migraine, periodontal disease, gingivitis, male infertility, and statin-induced myopathy. 7-10 Clinical trials have shown benefits for a wide range of cardiovascular conditions, including congestive heart failure, hypertension, and prevention of myocardial infarction. High-dose CoQ10, ranging up to 2400 mg per day, has been used primarily for neurodegenerative diseases such as Parkinson’s and Huntington’s disease, though elevated doses have also been used in patients with severe cardiovascular disease or advanced breast cancer. 3,4 CoQ10 supports cardiac tissues by improving endothelial function and by having a direct anti-atherogenic effect, which results in lower blood pressure and improved ventricular contractility. 1,2 It inhibits peroxidation of cell membrane lipids as well as circulating lipoproteins. It is a coenzyme for numerous reactions involved in cellular respiration, and is required for the efficient formation of adenosine triphosphate (ATP), the cellular currency which drives the majority of enzymatic reactions. The majority of the clinical uses for CoQ10 are founded upon its role as an antioxidant, and its role in mitochondrial bioenergetics.
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